Oh Brother, Why Art Thou?

 a limited-time questline that was released on June 27, 2021. It the main questline for Act 3 of the Springfield Enlightened 2021 Event, progressing through it  all of the Act's personal prizes. It preceded by the main Act 2 questline, Om Is Where the Heart Is. It succeeded by the main Act 4 questline, Buddhism Sans.

Quests
*Only appears if the player has Prince Gautama.

**Only appears if the player has Wiggum.

***Only appears if the player has Barney.

****Only appears if the player has Advisor Frink.